Trainee of the Month – Sandra Hwang

Sandra is a member of the Rullo Lab. Her research focuses on reprogramming tumour-associated macrophages (TAMs) using bifunctional small molecules (CIRs) as it engages a polarization receptor on the TAM while redirecting the reprogrammed TAM to its tumour target. The complexity of cancer research has intrigued Sandra, and she was grateful for the opportunity to join Dr. Rullo’s lab as an undergraduate thesis student to show her the thrill of problem-solving and innovation and hopes to make a difference in people’s lives through research. In her free time, Sandra enjoys sports, video games, and listening to and playing music

1.  What is your current research focus?

Macrophages are often known for their ability to eliminate pathogens through phagocytosis. However, the role of macrophages can change depending on the environment they are in and the cytokines they are exposed to. This flexibility in their role can be exploited by tumour cells and lead to tumour-associated macrophages (TAMs) that aid in tumour growth.

In the past, the Rullo lab has developed bifunctional small molecules (CIRs) that acts as a bridge between immune cells and tumour targets, redirecting the immune cells to recognize and eliminate the tumour cells. My research focus is to reprogram these TAMs using CIRs, which engage a polarization receptor on the TAM, while redirecting the reprogrammed TAM to its tumour target

2.  What made you interested in pursuing cancer research?

Something that has always sparked curiosity for me toward cancer is the complexity of the disease, its fascinating adaptability to various environments and how “smart” it is. I truly fell in love with immunology and cancer research in my final undergraduate year, during which I was very fortunate to join Dr. Anthony Rullo’s lab as an undergraduate thesis student. This experience showed me the thrill of problem-solving and innovation and ignited a new passion for me to one day make a difference in other’s lives with our research.

3.  What are your interests outside the CDCR and the lab?

Outside of the lab, I enjoy playing sports and playing video games with friends. I’m also a big fan of music, whether playing or listening. Other times, I love spending time with brothers and sisters in Christ while serving the Hamilton community alongside them.